The Picnic
    We hope that those of you who came to the picnic enjoyed it, and we congratulate all of our 50- and 60-year members, and the other award winners!
 September Dinner Meeting

David Lustig
    David Lustig received his Ph.D. in analytical chemistry from the University of Michigan in 1991.  His dissertation research focused on novel laser ionization mass spectrometric techniques for biomolecules.
    David has over 15 years of drug discovery and development experience in the pharmaceutical industry starting in the core mass spectrometry lab at Syntex and then moving into DMPK/ADME groups at Roche Bioscience and CV Therapeutics. David has served in roles including individual contributor, head of discovery bioanalysis, DMPK representative to drug discovery project teams, steering committee member for outside research collaborations and member of the Research Management Committee at CV Therapeutics  (CVT) overseeing all preclinical discovery projects. At CVT, David moved into business development where he was responsible for in-licensing and out-licensing of cardiovascular drugs.  David is currently a member of the senior management team at Optivia Biotechnology, a transporter technology company in Menlo Park, CA.
The Role of Transporters in Drug Discovery:
Developments for Improving Safety and Efficacy
    Since the 1976 discovery of the transmembrane P-glycoprotein efflux pump (P-gp) and the role it plays in acquired resistance to oncology drugs, much has been learned about active transporters. More than 350 human transporters have since been discovered including both efflux and uptake pumps.  It is now known that transporters can mediate both drug safety and efficacy since they can be responsible for absorption, distribution, metabolism and elimination of substrates.
    Transport activity has explained many clinical observations such as the unsafe adverse reactions experienced when co-administering digoxin with verapamil or quinidine.  The FDA has recognized the importance of transporter based drug-drug interactions (DDI) and has included 25 major human transporters in the 2006 Draft Guidance "Drug Interaction Studies — Study Design, Data Analysis, and Implications for Dosing and Labeling".
    This talk provides an overview of transporters and examines case studies in which transporters retrospectively explained the safety and efficacy of approved drugs.  Additionally, it presents drug discovery strategies for the prospective use of transporters to design compounds with better bioavailability and targeted tissue distribution for safer, more efficacious therapies.
 
Where: 

 

 Biltmore Hotel and Suites (click here for a map of the Biltmore's location)
2151 Laurelwood Road
Santa Clara,  CA  95054
  When:      Thursday, September 18, 2008
6:00 p.m.   Social hour
7:00 p.m.  Dinner
8:00 p.m.   Lecture
Menu:
 

 

 Chicken Cannelloni
OR
Vegetarian Pasta Primavera
(Wine is included with dinner)                                        

 Price:      $27.00/person (cash or check only; we can't do credit cards), as it has been at the Biltmore for some time now.

 Reservations: Needed by Monday, September 15, 2008  if you will be there for dinner.  Reservations are not needed if you are coming only for the lecture.

Name:
Employer or School:
Phone number:
Address (Home or Work):

Dinner entree (select one):
Chicken
Pasta

 If you are bringing guests, please indicate their names and affiliations (if any) below:
(You can also use this box to send in a cancellation or to ask for accommodation for special dietary needs.)


    Once you make a dinner reservation, we are committed to paying for your meal, whether or not you pay us. Please don't be a no-show! You may be invoiced for the meal if you make a reservation and then don't show up without canceling by Tuesday, September 16th!
    To cancel, just send in another reservation, and in the box labeled "If you are bringing guests...", write a brief note saying that you are canceling.

Future Meetings
     Please note that the further into the future we look, the more tentative the arrangements become.  But once we know, you'll see it here first!

    Our Chair Elect, Natalie McClure, has been a busy lady. Here's what she has in store for us. Some of the talk titles are tentative, but we expect no radical changes.
    Thursday, October 16: Stephan Habelitz of U.C. San Francisco will talk on "Rebuilding Teeth". (See C&EN for July 14, if you still have it.)
    Thursday, November 20: Terry Oldberg, "Maximizing Knowledge".
    Thursday, January 15: Chris McKay of NASA  will talk about exploring Mars. We currently have three active robots there sending us data.
    February: Nothing scheduled yet, but we do expect to have a dinner meeting in February.
    Thursday, March 19: Ted Brown will receive his Mosher Award. We usually present the Mosher Award in January, but Dr. Brown's schedule wouldn't permit that, so he'll be here in March.
    April or May; date to be announced when we know it: Joe Vinson, an ACS Tour Speaker, will talk on the biochemistry of coffee.
    Saturday, May 2: Ken Johnson of the Monterey Bay Aquarium Research Institute will talk on monitoring climate changes in the oceans. This will be a joint meeting with the Los Padres group at the aquarium. If there's sufficient interest, Natalie will arrange for a reduced rate at some local Monterey hotels for people who want to stay over.
    Can anyone help Natalie land a Nobel laureate for us? So far she has one turn-down.
    How about someone who can talk about nanotechnology?
    If you can help with either of these, please contact  .
Remember that certain dinner meetings are routinely pre-set: Mosher Award presentation and talk in January (although this year it's going to be in March), Student Affiliates meeting in April or May, Awards Picnic in late June or early July, no meetings at all in August or December.

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